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Título : Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning
Autor : Tomaz, Carlos Alberto Bezerra
Silva, A.C.F.
Nogueira, Paulo José de Campos
Assunto:: Substância P
Memória de longa duração
Fecha de publicación : 1997
Citación : TOMAZ, C.; SILVA, A. C. F.; NOGUEIRA, P. J. C. Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning. Brazilian journal of medical and biological research, v. 30, n. 2, p. 231-233, 1997. Disponível em: <http://www.scielo.br/pdf/bjmbr/v30n2/2635c.pdf>. Acesso em: 4 jan. 2011. doi: 10.1590/S0100-879X1997000200011.
Resumen : ABSTRACT
We investigated the long-lasting effect of peripheral injection of the neuropeptide substance P (SP) and of some N- or C-terminal SP fragments (SPN and SPC, respectively) on retention test performance of avoidance learning. Male Wistar rats (220 to 280 g) were trained in an inhibitory step-down avoidance task and tested 24 h or 21 days later. Immediately after the training trial rats received an intraperitoneal injection of SP (50 µg/kg), SPN 1-7 (167 µg/kg) or SPC 7-11 (134 µg/kg). Control groups were injected with vehicle or SP 5 h after the training trial. The immediate post-training administration of SP and SPN, but not SPC, facilitated avoidance behavior in rats tested 24 h or 21 days later, i.e., the retention test latencies of the SP and SPN groups were significantly longer (P<0.05, Mann-Whitney U-test) during both training-test intervals. These observations suggest that the memory-enhancing effect of SP is long-lasting and that the amino acid sequence responsible for this effect is encoded by its N-terminal part.
DOI: https://dx.doi.org/10.1590/S0100-879X1997000200011
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