Skip navigation
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/28309
Arquivos associados a este item:
Arquivo TamanhoFormato 
ARTIGO_BrazilianClinicalTrial.pdf286,2 kBAdobe PDFVisualizar/Abrir
Título: Brazilian clinical trial of uniform multidrug therapy for leprosy patients : the correlation between clinical disease types and adverse effects
Autor(es): Gonçalves, Heitor de Sá
Pontes, Maria Araci de Andrade
Bührer-Sékula, Samira
Cruz, Rossilene
Almeida, Paulo Cesar
Moraes, Maria Elisabete Amaral de
Penna, Gerson Oliveira
Assunto: Hanseníase
Efeitos adversos
Terapêutica
Data de publicação: Dez-2012
Editora: Instituto Oswaldo Cruz, Ministério da Saúde
Referência: GONÇALVES, Heitor de Sá et al. Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, supl. 1, p. 74-78, dez. 2012. DOI: https://doi.org/10.1590/S0074-02762012000900013. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900013&lng=en&tlng=en. Acesso em: 22 out. 2020.
Abstract: This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs. This quantitative, prospective, nested study was developed at the Dona Libânia Dermatology Centre in Fortaleza, Brazil. Data were collected from November 2007-November 2008. During this period, 818 leprosy patients were diagnosed and began treatment. Forty patients with tuberculoid leprosy (TT) were selected. Twenty patients followed a standard therapy of dapsone and rifampicin and 20 were administered dapsone, rifampicin and clofazimine (U-MDT). Twenty patients with borderline lepromatous (BL) and lepromatous leprosy (LL) were also selected and treated with U-MDT. All of the subjects received six doses. With the exception of haemolytic anaemia, there was a low incidence of adverse effects in all the groups. We did not observe any differences in the incidence of haemolytic anaemia or other side effects across groups of patients with TT, BL or LL treated with U-MDT.
Unidade Acadêmica: Faculdade de Medicina (FMD)
Licença: Memórias do Instituto Oswaldo Cruz - (CC BY-NC) - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900013&lng=en&tlng=en. Acesso em: 22 out. 2020.
DOI: https://dx.doi.org/10.1590/S0074-02762012000900013
Aparece nas coleções:Artigos publicados em periódicos e afins

Mostrar registro completo do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.