Title:	Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy patients may increase the risk of neural damage
Authors:	Morais Júnior, Gilberto Santos Kurizky, Patricia Shu Cerqueira, Selma Regina Penha Silva Barroso, Daniel Holanda Schulte, Heidi Luise Albuquerque, Cleandro Pires de Gois, Eliana Teles de Espindola, Laila Salmen Santana, Jaime Martins de Bastos, Izabela Marques Dourado Araújo, Carla Nunes de Mota, Licia Maria Henrique da Nóbrega, Otávio de Tolêdo Gomes, Ciro Martins
Assunto::	Hanseníase SARS-CoV-2 Covid-19
Issue Date:	2021
Publisher:	American Society of Tropical Medicine and Hygiene
Citation:	MORAIS JUNIOR, Gilberto Santos et al. Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy patients may increase the risk of neural damage. The American Journal of Tropical Medicine and Hygiene, v. 104, n. 6, p. 2190-2194, 2021. DOI: https://doi.org/10.4269/ajtmh.21-0034. Disponível em: https://www.ajtmh.org/view/journals/tpmd/104/6/article-p2190.xml. Acesso em: 26 jul. 2021.
Abstract:	Experts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the first peak of the COVID-19 epidemic in Brazil and analyzed the expressions of genes encoding interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12A, IL-12B, and tumor necrosis factor-α in peripheral blood mononuclear cells. We included 64 leprosy patients and 50 controls. Twelve of the leprosy patients and 14 of the controls had been diagnosed with COVID-19. Co-infection was associated with increased IL-6 (P = 0.043) and IL-12B (P = 0.017) expression. The median disability grades were higher for leprosy/COVID-19 patients; however, the difference was not significant (P = 0.194). Patients co-infected with M. leprae and SARS-CoV-2 may experience a higher-grade proinflammatory state.
Licença::	This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI:	https://doi.org/10.4269/ajtmh.21-0034
metadata.dc.relation.isbasedon:	https://repositorio.unb.br/handle/10482/40909
Appears in Collections:	Artigos publicados em periódicos e afins UnB - Covid-19

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