Title:	Seasonal chemical evaluation of Miconia chamissois Naudin from Brazilian Savanna
Authors:	Ferreira, Juliana de Freitas Mera López, Manuel Humberto Gomes, João Victor Dutra Martins, Diegue Henrique Nascimento Fagg, Christopher William Batista, Pérola de Oliveira Magalhães Dias Davies, Noel William Silveira, Dâmaris Bazzo, Yris Maria Fonseca
metadata.dc.identifier.orcid:	https://orcid.org/0000-0001-8727-0043 https://orcid.org/0000-0001-6098-3852 https://orcid.org/0000-0001-6072-7832 https://orcid.org/0000-0001-8011-6940 https://orcid.org/0000-0003-1851-5224 https://orcid.org/0000-0002-1230-3207
Assunto::	Miconia chamissois Sazonalidade Cerrados
Issue Date:	2022
Publisher:	MDPI
Citation:	FERREIRA, Juliana de Freitas et al. Seasonal chemical evaluation of Miconia chamissois Naudin from Brazilian Savanna. Molecules, v. 27, n. 3, 1120, 2022. DOI: https://doi.org/10.3390/molecules27031120. Disponível em: https://www.mdpi.com/1420-3049/27/3/1120. Acesso em: 5 maio 2022.
Abstract:	Miconia chamissois Naudin is a species from the Cerrado, which is being increasingly researched for its therapeutic potential. The aim of this study was to obtain a standardized extract and to evaluate seasonal chemical variations. Seven batches of aqueous extracts from leaves were produced for the standardization. These extracts were evaluated for total solids, polyphenol (TPC) and flavonoid content (TFC), vitexin derivative content, antioxidant activity; thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) profiles were generated. For the seasonal study, leaves were collected from five different periods (May 2017 to August 2018). The results were correlated with meteorological data (global radiation, temperature, and rainfall index). Using chromatographic and spectroscopic techniques, apigenin C-glycosides (vitexin/isovitexin) and derivatives, luteolin C-glycosides (orientin/isoorientin) and derivatives, a quercetin glycoside, miconioside B, matteucinol-7-O-β-apiofuranosyl (1 → 6) -β-glucopyranoside, and farrerol were identified. Quality parameters, including chemical marker quantification by HPLC, and biological activity, are described. In the extract standardization process, all the evaluated parameters showed low variability. The seasonality study revealed no significant correlations (p < 0.05) between TPC or TFC content and meteorological data. These results showed that it is possible to obtain extracts from M. chamissois at any time of the year without significant differences in composition.
Licença::	(CC BY)
DOI:	https://doi.org/10.3390/molecules27031120
Appears in Collections:	Artigos publicados em periódicos e afins

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