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Título: Seasonal chemical evaluation of Miconia chamissois Naudin from Brazilian Savanna
Autor(es): Ferreira, Juliana de Freitas
Mera López, Manuel Humberto
Gomes, João Victor Dutra
Martins, Diegue Henrique Nascimento
Fagg, Christopher William
Batista, Pérola de Oliveira Magalhães Dias
Davies, Noel William
Silveira, Dâmaris
Bazzo, Yris Maria Fonseca
ORCID: https://orcid.org/0000-0001-8727-0043
https://orcid.org/0000-0001-6098-3852
https://orcid.org/0000-0001-6072-7832
https://orcid.org/0000-0001-8011-6940
https://orcid.org/0000-0003-1851-5224
https://orcid.org/0000-0002-1230-3207
Assunto: Miconia chamissois
Sazonalidade
Cerrados
Data de publicação: 2022
Editora: MDPI
Referência: FERREIRA, Juliana de Freitas et al. Seasonal chemical evaluation of Miconia chamissois Naudin from Brazilian Savanna. Molecules, v. 27, n. 3, 1120, 2022. DOI: https://doi.org/10.3390/molecules27031120. Disponível em: https://www.mdpi.com/1420-3049/27/3/1120. Acesso em: 5 maio 2022.
Abstract: Miconia chamissois Naudin is a species from the Cerrado, which is being increasingly researched for its therapeutic potential. The aim of this study was to obtain a standardized extract and to evaluate seasonal chemical variations. Seven batches of aqueous extracts from leaves were produced for the standardization. These extracts were evaluated for total solids, polyphenol (TPC) and flavonoid content (TFC), vitexin derivative content, antioxidant activity; thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) profiles were generated. For the seasonal study, leaves were collected from five different periods (May 2017 to August 2018). The results were correlated with meteorological data (global radiation, temperature, and rainfall index). Using chromatographic and spectroscopic techniques, apigenin C-glycosides (vitexin/isovitexin) and derivatives, luteolin C-glycosides (orientin/isoorientin) and derivatives, a quercetin glycoside, miconioside B, matteucinol-7-O-β-apiofuranosyl (1 → 6) -β-glucopyranoside, and farrerol were identified. Quality parameters, including chemical marker quantification by HPLC, and biological activity, are described. In the extract standardization process, all the evaluated parameters showed low variability. The seasonality study revealed no significant correlations (p < 0.05) between TPC or TFC content and meteorological data. These results showed that it is possible to obtain extracts from M. chamissois at any time of the year without significant differences in composition.
Licença: (CC BY)
DOI: https://doi.org/10.3390/molecules27031120
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