Título:	Therapeutic effects of Zymomonas mobilis on experimental DSS-Induced colitis mouse model
Autor(es):	Almo, Manuela Maragno do Sousa, Isabel Garcia Olinto, Vitor Guimarães Pinhate, Sylvia Barbosa Jivago, José Luiz de Paula Rôlo Sousa, Davi Emanuel Ribeiro de Castro, Márcio Botelho de Rubini, Marciano Régis Maranhão, Andrea Queiroz Brigido, Marcelo Macedo
ORCID:	https://orcid.org/0000-0002-0361-7730 https://orcid.org/0000-0002-6326-9803 https://orcid.org/0000-0003-1237-0693 https://orcid.org/0000-0002-3996-0856 https://orcid.org/0000-0002-1946-7191 https://orcid.org/0000-0002-7136-7059
Afiliação do autor:	University of Brasilia, Institute of Biological Sciences, Department of Cell Biology University of Brasilia, Medicine Faculty, Molecular Pathology Graduation Program University of Brasilia, Institute of Biological Sciences, Department of Cell Biology University of Brasilia, Institute of Biological Sciences, Department of Cell Biology University of Brasilia, Institute of Biological Sciences, Molecular Biology Graduation Program University of Brasilia, Institute of Biological Sciences, Department of Cell Biology University of Brasilia, Institute of Biological Sciences, Molecular Biology Graduation Program University of Brasilia, Institute of Biological Sciences University of Brasilia, Veterinary Pathology Laboratory University of Brasilia, Veterinary Pathology Laboratory Embrapa Agroenergy, Laboratory of Genetics and Molecular Biology University of Brasilia, Institute of Biological Sciences, Department of Cell Biology National Institute of Science and Technology (iii-INCT), Institute for Immunology Investigation University of Brasilia, Institute of Biological Sciences, Department of Cell Biology National Institute of Science and Technology (iii-INCT), Institute for Immunology Investigation
Assunto:	Bactérias Colite Microbiota Imunomodulação Probióticos
Data de publicação:	17-Nov-2023
Editora:	MDPI
Referência:	ALMO, Manuela Maragno do et al. Therapeutic effects of Zymomonas mobilis on experimental DSS-Induced colitis mouse model. Microorganisms, [S. l.], v. 11, n. 11, 2023. DOI: https://doi.org/10.3390/microorganisms11112793. Disponível em: https://www.mdpi.com/2076-2607/11/11/2793. Acesso em: 22 out. 2024.
Abstract:	Zymomonas mobilis, a Gram-negative bacteria observed in some popular beverages, is considered safe and has been studied for its potential therapeutic benefits. In this study, we explored its effects on the inflammatory process, tissue integrity, differential gene expression, and microbiota composition in an experimental dextran sulfate sodium (DSS)-induced colitis model in mice. As a result, Z. mobilis alleviated the symptoms caused by DSS administration, as indicated by reduced weight loss, disease activity index, a significant reduction in the colon weight/length ratio, and histopathological improvement. Also, Z. mobilis could restore the mucosal barrier as well as increase the expression of Muc3 and Ocln genes. An analysis of 16S rRNA sequences showed that Z. mobilis alters gut microbiota, increasing Akkermansia muciniphila abundance and decreasing Escherichia coli. Furthermore, Z. mobilis seems to be involved in potentiating a regulatory phenotype by inducing immunomodulatory genes like Tgfb, Il5, Il10, and Foxp3 and reducing the relative mRNA expression of proinflammatory cytokines TNF, Il6, and Il17. Our data suggest that Z. mobilis could alleviate disease progression and be considered a possible probiotic adjuvant for pathologies of the bowel.
Unidade Acadêmica:	Instituto de Ciências Biológicas (IB) Departamento de Biologia Celular (IB CEL) Faculdade de Medicina (FM) Faculdade de Agronomia e Medicina Veterinária (FAV)
Programa de pós-graduação:	Programa de Pós-Graduação em Patologia Molecular Programa de Pós-Graduação em Biologia Molecular Programa de Pós-Graduação em Ciências Animais
Licença:	© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)
DOI:	https://doi.org/10.3390/microorganisms11112793
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