Title:	Direct and abscopal antitumor responses elicited by AlPcNE-mediated photodynamic therapy in a Murine melanoma model
Authors:	Morais, José Athayde Vasconcelos Barros, Pedro Henrique Aragão Brígido, Marcelo de Macedo Marina, Clara Luna Bocca, Anamélia Lorenzetti Mariano, André de Lima e Silva Souza, Paulo Eduardo Narcizo de Paiva, Karen Letycia Rodrigues de Simões, Marina Mesquita Báo, Sonia Nair Camargo, Luana Cristina Longo, João Paulo Figueiró Morais, Amanda Alencar Cabral Azevedo, Ricardo Bentes de Fonseca, Marcio José Poças Muehlmann, Luis Alexandre
metadata.dc.identifier.orcid:	https://orcid.org/0000-0003-3067-4842 https://orcid.org/0000-0002-7136-7059 https://orcid.org/0000-0002-0819-0756 https://orcid.org/0000-0003-3323-5300 https://orcid.org/0000-0001-8013-8250 https://orcid.org/0000-0002-4289-8678 https://orcid.org/0000-0002-2098-4401 https://orcid.org/0000-0002-9814-5827 https://orcid.org/0000-0002-9873-3098 https://orcid.org/0000-0002-7223-037X https://orcid.org/0000-0002-5154-7263 https://orcid.org/0000-0002-6974-0889 https://orcid.org/0000-0002-2137-9588 https://orcid.org/0000-0003-4711-7583
metadata.dc.contributor.affiliation:	University of Brasilia, Faculty of Ceilandia, Laboratory of Nanoscience and Immunology University of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Gene Regulation and Mutagenesis University of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Gene Regulation and Mutagenesis University of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Gene Regulation and Mutagenesis University of Brasília, Institute of Biological Sciences, Laboratory of Applied Immunology University of Brasília, Institute of Biological Sciences, Laboratory of Applied Immunology University of Brasilia, Institute of Physics, Laboratory for Softwares and Physics Instrumentation Development University of Brasilia, Institute of Physics, Laboratory for Softwares and Physics Instrumentation Development University of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysis University of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysis University of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysis University of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnology University of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnology University of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnology University of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnology University of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Gene Regulation and Mutagenesis
Assunto::	Sistema imunológico Imunoterapia Nanoemulsão Melanoma
Issue Date:	6-Sep-2024
Publisher:	MDPI
Citation:	MORAIS, José Athayde Vasconcelos et al. Direct and abscopal antitumor responses elicited by AlPcNE-mediated photodynamic therapy in a Murine melanoma model. Pharmaceutics, [S. l.], v. 16, n. 9, 1177, 2024. DOI: https://doi.org/10.3390/pharmaceutics16091177. Disponível em: https://www.mdpi.com/1999-4923/16/9/1177. Acesso em: 17 fev. 2025.
Abstract:	Melanoma, the most aggressive form of skin cancer, presents a major clinical challenge due to its tendency to metastasize and recalcitrance to traditional therapies. Despite advances in surgery, chemotherapy, and radiotherapy, the outlook for advanced melanoma remains bleak, reinforcing the urgent need for more effective treatments. Photodynamic therapy (PDT) has emerged as a promising alternative, leading to targeted tumor destruction with minimal harm to surrounding tissues. In this study, the direct and abscopal antitumor effects of PDT in a bilateral murine melanoma model were evaluated. Although only one of the two tumors was treated, effects were observed in both. Our findings revealed significant changes in systemic inflammation and alterations in CD4+ and CD8+ T cell populations in treated groups, as evidenced by blood analyses and flow cytometry. High-throughput RNA sequencing (RNA-Seq) further unveiled shifts in gene expression profiles in both treated and untreated tumors. This research sheds light on the novel antitumor and abscopal effects of nanoemulsion of aluminum chloride phthalocyanine (AlPcNE)-mediated PDT in melanoma, highlighting the potential of different PDT protocols to modulate immune responses and to achieve more effective and targeted cancer treatments
metadata.dc.description.unidade:	Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia Instituto de Ciências Biológicas (IB) Departamento de Genética e Morfologia (IB GEM) Departamento de Biologia Celular (IB CEL) Instituto de Física (IF)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Biologia Animal
Licença::	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
DOI:	https://doi.org/10.3390/pharmaceutics16091177
Appears in Collections:	Artigos publicados em periódicos e afins

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